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Manufacturing vaccines today is inefficient due to the use of serial batch operations in large complex facilities that require highly trained operators and extensive quality testing throughout production. The Vax-Hub will seek to enhance future Vaccine Manufacturing through continued innovation. Platform funding via Feasibility Projects and Expert Interaction Vouchers will be available to enable users to test these novel outputs on their own products and processes, thus adding to the innovation pipeline. The Grand Challenge research will generate significant amounts of data, protocols and increase process understanding, which will be disseminated via training activities. Platform Funding: Platform funding will enable knowledge transfer activities and feasibility studies, both within the UK and internationally.This will require new modelling tools to describe the impact on cost and study optimal manufacturing strategies. Grand Challenge 2: Enhanced operational and economic tools for uninterrupted, low-cost supply, will consider the integration of new technologies and process improvements established in Grand Challenge 1 and their real impact on the cost of goods.Grand Challenge 1: Tools and technologies to de-risk scale-up and rapid response, which will encompass research into new de-risking tools and technologies, platform manufacturing, analytics and formulation for new and existing vaccines.The Vax-Hub will work with its network of users and academics to deliver the vision, with the core research focusing on: Policy: Shape UK and international policy through continued leadership in vaccine research, user group interactions and manufacturer and funder engagement.Pipeline: Increase the number of products entering and succeeding in the development pipeline with development tools.Economy: Increase value to the economy through cost savings achieved through decisional tools and cheaper vaccines.
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Skills: Increase academic, industrial and policy training through secondments, continuing professional development (CPD), Qualified Person training and dissemination events.Health: Ensure that fewer people die from vaccine-preventable diseases through the timely, affordable supply of vaccine, for both routine and emergency scenarios.The Vax-Hub vision is to make the UK the global centre for integrated discovery through to bioprocess manufacture of next-generation vaccines: The Future Vaccine Manufacturing Research Hub: securing the supply of essential vaccines What will the Future Vaccine Manufacturing Research Hub (Vax-Hub) achieve?
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